NCATS Assay Guidance Workshop on Sample Management

Thu, Oct 26, 2023, 9:00 AM – 12:15 PM EDT

Video of this event is available from the NIH VideoCast site

About the Workshop

The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) program is hosting a half-day workshop that will cover a broad range of critical concepts, including practical approaches to, and best practices in, sample management. This workshop will also cover emerging technologies and trends in sample management, including novel platforms, and management of biologics, antisense oligonucleotides, natural products, and others. This workshop is organized in memory of our colleague, Paul Shinn, who passed away last fall. Paul was a foundational member of NCATS and its Division of Preclinical Innovation (DPI)’s compound management group leader. 

Goals and Objectives

  • Provide participants with fundamentals on sample management.
  • Disseminate best practices in sample management.
  • Introduce participants to emerging trends and technologies in sample management.
  • Share experiences and seek practical advice about individual research concerns.


Download the agenda


About the Assay Guidance Manual

The Assay Guidance Manual (AGM) is a free, best-practices online resource devoted to the successful development of robust, early-stage drug discovery assays.

The manual was originally developed to provide step-by-step guidance based on experiential knowledge from drug developers for planning and executing projects in high-throughput screening, lead optimization and early phases of drug development. The AGM has now been expanded into a unique, user-friendly collection of over 50 chapters of well-tested knowledge, much of which is being documented for the first time. Methods outlined in the manual address appropriate statistical ways to analyze assay results and accommodate minor changes to assay protocols to ensure robustness.

Investigators worldwide can use the manual to design biologically and pharmacologically relevant assays for high-throughput screening and lead optimization to evaluate collections of molecules that modulate the activity of biological targets, pathways and cellular phenotypes.

The National Center for Advancing Translational Sciences (NCATS) manages the content of the manual with input from industry, academia and government experts. More than 100 authors from around the world have contributed content to this free resource, which is updated regularly and housed by the National Library of Medicine. The chapters have PubMed citations for the contributing authors.

Workshop Organizing Committee

Kyle Brimacombe, NCATS

Abigail Grossman, NCATS

Rajarshi Guha, Vertex Pharmaceuticals

Matthew D. Hall, NCATS

Sarine Markossian, NCATS

Lesley Mathews, SLAS

Sam Michael, NCATS

Kelli Wilson, NCATS

This workshop was supported by the Intramural Research Program of the NCATS, NIH.



Ajit Jadhav

Director, Digital, Worldwide Research, Development and Medical, Pfizer

Brice A.P. Wilson

Staff Scientist, Molecular Targets Program, Center for Cancer Research, NCI

David A. Hayes

Director, North American Operations; Specs Division, eMolecules

Kelli M. Wilson

Director of Compound Management, NCATS

Kristen Nailor

Principal Scientific Manager, Drug Discovery Sample & Data Management; Lead, Biologics Sample Management, Genentech, Inc.

Larry Callahan

Chemist, FDA

Lesley Mathews

Scientific Director, Society for Laboratory Automation and Screening

Pierre Baillargeon

Senior Data Architect, TetraScience

Sam Michael


Sarine Markossian

Editor-in-Chief, Assay Guidance Manual; Lead, Translational Science Resources Program, NCATS

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